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FX 1 is a versatile hybrid bike at a great value. It's built with a lightweight aluminum frame, performance parts that keep the price in check, and strong wheels built on double-walled rims. This hybrid is perfectly suited to a variety of uses, from casual riding to exercise and commutes.
When flying the FX1 it is more likely you will need to land and use a restroom before your fuel tanks run dry. For example if you fly a 912iS at 97 ktas and 3.7 gph, you will cover 794 nm, in 8 hours 10 minutes and burn 31 gallons of fuel.
The FX1 is Alfredo Di Cesare’s latest and best design, with a totally new airframe that incorporates countless improvements and refinements. He has produced a high-performance sport plane that reflects his great sense of style, his attention to detail, and his high standards for airworthiness and safety. Request a Brochure & Pricing ...
FX1 is a potent and specific BCL6 inhibitor, with an IC50 of around 35 μM. DLBCL cells are exposed to 50 μM FX1 for 30 minutes. FX1 profoundly reduces recruitment of BCOR and SMRT to all 3 BCL6 target genes, but not at a negative control locus. There is little presence of SMRT at these loci in the BCL6-negative DLBCL cell line, which is not ...
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FX1 is a selective BCL6 BTB inhibitor with an IC50 value of 35 μM in reporter assays. FX1 shows great selectivity against a panel of 50 different kinases. 10 μM FX1 fails to significantly inhibit of any of these kinases. FX1 induces apoptosis. FX1 disrupted formation of the BCL6 repression complex, reactivated BCL6 target genes, and mimicked ...
FX1 decreased the production of inflammatory cytokines, attenuated macrophage infiltration activities and reduced monocytes chemotaxis activities, all of which suggest that FX1 exert anti-inflammatory effects. Mechanistically, FX1 may enhance the affinity of BCL6 binding to downstream target pro-inflammatory genes.
FX1 is a BCL6 inhibitor that effectively blocks BCL6 N-terminal BTB domain-mediated corepressors chromosome recruitment (by 61-87%/SMRT and 67-82%/BCOR; 50 μM FX1 for 30 min) and selectively suppresses BCL6-depenent growth (GI50 16-54 μM; >125 μM against BCL6-independent cells) in diffuse large B cell lymphoma (DLBCL) cultures, exhibiting greater affinity than its structure analog 79-6 or ...
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Contact. Fx1 Inc 815 Ponce De Leon Blvd P205, 33134 Coral Gables, Florida, USA
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