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ROCK2 Gene - Rho Associated Coiled-Coil Containing Protein Kinase 2. ROCK2. Inhib. RNA. The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element.
Moreover, ROCK2 inhibition shifts the Th17/regulatory T (Treg) cell balance toward Treg cells and restores immune homeostasis in animal models of autoimmunity and cGVHD. Furthermore, the selective inhibition of ROCK2 by belumosudil reduces fibrosis by downregulating both transforming growth factor-β signaling and profibrotic gene expression ...
RhoBTB1 associates with ROCK1 and ROCK2 and its association with ROCK1 is via its Rho domain. Results show that rhoC GTP-binding protein (RhoC)/Rho-associated, coiled-coil containing protein kinase 2 (ROCK2) may have a major effect on VM in hepatocellular carcinoma (HCC) via ERK/MMPs signaling and might be a potential therapeutic target for the ...
ROCK2, but not ROCK1, controls the balance between pro-inflammatory and Treg cell subsets. ROCK signaling is critical in the coordination of T-cell–mediated immune responses, including cellular movement, cell proliferation and the acquisition of the appropriate T-cell effector phenotype [, , ].
ROCK2. Rho associated coiled-coil containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene . Fasudil is an inhibitor of ROCK protein.
This study thus indicated that catalpol, via inhibition of the RhoA/ROCK2 signaling pathway, reverses the disaggregation of cytoskeleton actin in BMECs and prevents down-regulation of junctional proteins, such as claudin-5, occludin, and ZO-1, and decreases endothelin-1 and inflammatory cytokine secretion, eventually alleviating the increase in ...
The Rho kinase (ROCK) isoforms, ROCK1 and ROCK2, were initially discovered as downstream targets of the small GTP-binding protein Rho. Because ROCKs mediate various important cellular functions such as cell shape, motility, secretion, proliferation, and gene expression, it is likely that this pathway will intersect with other signaling pathways known to contribute to cardiovascular disease.
Previous findings demonstrated that inhibition of ROCK2 in healthy patients decreases IL-17 and IL-21 production. 20 ROCK2 inhibition by KD025 also shifted the balance of effector cells to T regulatory cells. 20 These findings are supported by demonstration of the importance of ROCK2 during autoimmune diseases such as systemic lupus ...
The inactive form of RhoA is converted into RhoA-GTP, which activates ROCK2 (MYPT-1 is a specific substrate, and the p-MYPT-1/MYPT-1 ratio is an indicator of the activity of ROCK2). Activated ROCK2 induces MYPT1 and MLC phosphorylation .
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Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM.
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